DEPAKENE Tablets 200mg

Generic name: Sodium Valproate

Manufactured by: Kyowa Kirin

Description

This medicine is considered to suppress development of migraine via gamma-aminobutyric acid (GABA, an inhibitory neurotransmitter) in the brain.

It is usually used in the treatment of migraine to prevent or relieve development of migraine. It does not improve migraine which has already developed.

Ingredients and dosage form

yellow tablet, φ: 9.2 mm, thickness: 4.9 mm

Dosing schedule/Directions

In general, take 2 to 4 tablets (400-800 mg of the active ingredient) daily, in two or three divided doses. The dosage may be adjusted according to the age or symptoms. However, the dosage is restricted up to 5 tablets (1,000 mg) a day. Strictly follow the instructions.

If you missed a dose, take a dose as soon as possible. After taking the medicine, wait about 4 hours to take the next dose. You should never take two doses at one time.

If you accidently took too much of the medicine (more than instructed), check with your doctor/pharmacist.

Do not stop taking this medicine unless your doctor instructs you to do so.

Warnings

Before using this medicine, be sure to tell your doctor and pharmacist

If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.

If you are a patient with hepatic disorder, encephalopathy or coma of unknown cause, or urea cycle disorder.

If you have a family history of infant death of unknown cause.

If you are pregnant, possible pregnant or breastfeeding.

If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Precautions while taking this medicine

The medicine may cause drowsiness, lowering of attentiveness, concentration and reflex motor activities. Avoid driving a car or operating dangerous machinery.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include somnolence, ataxia or light-headed feeling, nausea, vomiting, loss of appetite, gastrointestinal disorder and general malaise. If any of these symptoms occur, consult with your doctor or pharmacist.

The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.

general malaise, loss of appetite, nausea, yellowing in skin and white of eyes [hepatic disorder such as fulminant hepatitis]

general malaise, loss of appetite, somnolence, light-headed feeling [consciousness disturbance associated with hyperammonemia]

general malaise, dizziness, bruise [hemolytic anemia, pure red-cell aplasia, pancytopenia, thrombocytopenia, granulocytopenia]

intense abdominal pain, fever, nausea [acute pancreatitis]

fever, general malaise, loss of appetite, rash [oculomucocutaneous syndrome, toxic epidermal necrolysis]

dry cough, shortness of breath, fever [interstitial pneumonia, eosinophilic pneumonia]

The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

For healthcare professional use only.

For further information, talk to your doctor or pharmacist.

Storing Conditions

This medicine is susceptible to moisture. Store with care, do not take out the tablet from the sheet or damage the package.

Keep out of the reach of children. Store away from direct sunlight, heat and moisture.

Discard the remainder, do not store.

Product specifications, appearance and package content are subject to change without prior notice.

Description of the medical drugs is not intended for prescribing treatment without the involvement of a physician.