COLCHICINE 0.5mg (TAKATA)

Generic name: Colchicine

Manufactured by: TAKATA Pharmaceutical

Description

This medicine prevents gout attacks by suppressing leukocyte actions on the uric acid in the joints.

It also controls symptoms of familial Mediterranean fever by acting on microtubules and consequently suppressing inflammatory cytokine production.

It is usually used to prevent/treat gout attacks or treat familial Mediterranean fever. However, it does not cure the causes of the disease in itself.

Ingredients and dosage form

blue tablet, diameter: approximately 7.0 mm, thickness: approximately 2.1 mm

Dosing schedule/Directions

Your dosing schedule must be prescribed by your doctor or a healthcare professional.

During attack: In general, for adults, take 1 tablet (0.5 mg of the active ingredient) at a time every 3 to 4 hours, 6 to 8 times a day. The dosage may be adjusted according to your age or symptoms. The daily dose is 1.8 mg.

Attack prevention: In general, for adults, take 1 to 2 tablets (0.5 to 1 mg of the active ingredient) a day.

Feeling (a hunch) of attack: In general, for adults, take 1 tablet (0.5 mg of the active ingredient) at a time.

Familial Mediterranean fever: In general, for adults, take 1 tablet (0.5 mg of the active ingredient) at a time in 1 to 2 divided doses. The dosage may be adjusted according to your age or symptoms. The maximum daily dose is 1.5 mg. In general, for children, take 0.01 to 0.02 mg/kg of the active ingredient a day in 1 to 2 divided doses. The dosage may be adjusted according to your age or symptoms.

In any case, strictly follow the instructions.

If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose. You should never take two doses at one time.

If you accidentally take more than your prescribed dose, check with your doctor or pharmacist.

Do not stop taking this medicine unless your doctor instructs you to do so.

Warnings

Before using this medicine, be sure to tell your doctor and pharmacist

If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.

If you have liver disorder or renal disorder.

If you are pregnant, possibly pregnant or breastfeeding.

If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Precautions while taking this medicine

Grapefruit juice may intensify the medicinal effect of this medicine.

Pay attention not to take this medicine with grapefruit juice.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include diarrhea, nausea, vomiting, abdominal pain, rash, generalized itching, fever, hair loss, bloody urine, oliguria. If any of these symptoms occur, consult with your doctor or pharmacist.

The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.

・bleeding tendency, sore throat, fever [aplastic anemia, granulocytopenia, leukopenia, thrombocytopenia]

・muscle pain, weakness in the limbs, dark urine (reddish brown urine) [rhabdomyolysis, myopathy]

・numbness/pain/sensory paralysis of limbs [peripheral nerve impairment]

The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storing Conditions

・Keep out of the reach of children.

・Store away from light, heat and moisture.

・Discard the remainder.

・Do not store them.

・Ask the pharmacist and the medical institution how to discard them.

Product specifications, appearance and package content are subject to change without prior notice.

Description of the medical drugs is not intended for prescribing treatment without the involvement of a physician.